Neuropeptide Deep Crease Serum, 1 oz.

$189.00
Size:1.00 oz
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Product details

Web ID: 25409545

Targeted skin refinement begins with this Perricone MD Neuropeptide Deep Crease Serum focused on improving the look of lines around the mouth, eyes, lips, and forehead. Neuropeptides and plant stem cells help support wrinkle reduction and improve the appearance of skin density for a smoother look.

  • Product Features

    • WHAT IT IS:
    • A highly-potent silky serum.
    • WHAT IT DOES:
    • Helps smooth the look of even the most stubborn, deep lines, wrinkles, and creases around the mouth, eyes, lips & forehead. Reduces the appearance of deep creases, marionette & lip lines.
    • INGREDIENT HIGHLIGHTS:
    • Formulated with neuropeptides, peptides
    • SKIN TYPES:
    • Suitable for all skin types
    • HOW TO USE:
    • After cleansing, massage onto face & neck using a gentle upward motion. Wait until fully absorbed & follow with your favorite Perricone MD moisturizer. Use morning and evening.
  • Shipping & Returns

    • This item qualifies for Free Shipping with minimum purchase! exclusions & details
    • California and Minnesota customers call 1-800-289-6229 for Free Shipping information.
    • For complete details, see our Shipping and Returns policies.

Ratings & Reviews

Here's what customers think
  • The Neuropeptide Deep Crease Serum is an effective anti-aging product that helps smooth and soften the appearance of deep wrinkles and expression lines.
  • Users reported noticeable improvements in the depth and visibility of lines after consistent use.
  • The serum has a luxurious, silky texture that absorbs quickly without leaving a greasy or sticky residue.
  • It is formulated with neuropeptides, biomimetic growth factor peptides, and plant stem cells to help boost skin elasticity and reduce the look of deep creases.
  • Many users found the serum to be hydrating and leave their skin looking more plump and radiant.
AI-generated summary from 714 customers reviews.

4.5/5

714 star ratings & reviews

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External reviewer
5 days ago

Deep Crease Serum

This product is awesome. I started noticing creases around my mouth and use this twice a day and they have really started to fade. 5 stars!!

Customer review from Perricone MD

MP05
9 days ago
Incentivized review

Premium product, premium results

Once again, Influenster and Dr Perricone comes along with a phenomenal product! Thai was given to me to try and let me tell you, what a great, easy, premium product this is! First- it’s unavoidable to mention it is a premium product with a premium price point. BUT- it responds with premium results! I started using this as my go to serum, preceded by my face wash, toner and essence. After those steps, I apply a reasonable amount of this (about half a dime sized drop) and I applied it to the sides of my nose, where smile lines are. It absorbs nicely and isn’t sticky or tacky. I finish with a simple moisturizer and that’s it. At first, no big deal… but after about 2 weeks, I have noticed some softening of these crease lines. Mind you I’ve had them a while, so I’m definitely managing expectations here. But the fact that after only 2 weeks I’ve seen them start to soften, and from a topical- I’ll take it! I’m eager to see how it goes in 2 months. I really appreciate that this is a very smooth, absorbable serum. No issues with pilling or feeling heavy. I am a bit concerned about the maintenance once I finish this, as it is a truly premium priced product, but if it works, it’s definitely a lot less than injectables and cos med interventions. I’ll keep applying it and look forward to the results!

Customer review from influenster.com

Meg
11 days ago

Great

I brought a month ago so pleased I did, can notice a bug difference, less deep wrinkles.

Customer review from Perricone MD

Response from Perricone MD

Perricone MD Customer Care10 days ago

That's fantastic to hear! We're so glad you’re seeing a noticeable difference and those deep wrinkles are less visible. Thank you for sharing your experience, your results make us so happy.

BrittaN
16 days ago
Incentivized review

Such a gentle serum- love it!

I tried this serum because of my smile lines and was pleasantly surprised. It’s lightweight but still hydrating and with regular use those lines look a lot softer and less noticeable. My skin feels firmer after all. It’s not an overnight fix but I did see a difference over time.

Customer review from influenster.com

Judy
22 days ago

Wrinkles gone!

I’ve used this wrong mole treatment for almost one year. I’m 83 with hardly a deep wrinkle. It’s a miracle cream!!

Customer review from Perricone MD

Response from Perricone MD

Perricone MD Customer Care22 days ago

We love hearing this—thank you for sharing your experience! So glad it’s been working so wonderfully for you.

AlisaJ
24 days ago
Incentivized review

Gentle results

This serum is a good hydrator to help plump skin and as a result, reduce the visibility of creases. I used it awhile to ensure I could write an informed review, and while it didn’t eliminate any creases (I have one horizontal one on my neck plus deep nasolabial folds, those areas did appear smoother than before. The dropper was a little weird in that I could only get about one drop at a time but I guess it helped not waste product.

Customer review from influenster.com

SarahZ
28 days ago
Incentivized review

High potent results

This high potential deep crease serum if full of super power ingredients, neuro peptides, that helps smooth those pesky wrinkles. It’s a luxury product and you def get the results you’re looking for.

Customer review from influenster.com

LeticiaB
1 month ago
Incentivized review

Does what it says.

I am not new to Perricone MD products, so I was excited to try their deep crease serum. Especially, now that I’m older, I have seen a change in my skin. Especially the elasticity, texture, and increase in fine lines and wrinkles. I have deep smile lines that make my makeup application difficult. Using this product has made them smoother and less noticeable even without makeup use. These pictures are months apart and my no makeup look is much more improved than my makeup look. And this is without consistent nightly use. I’m very pleased with my results.

Customer review from influenster.com